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1. Risk of Recurrent Respiratory and CNS Depression: Due to the duration of action of naloxone relative to the opioid, keep the patient under continued surveillance and administer repeat doses of naloxone using a new nasal spray with each dose, as necessary, while awaiting emergency medical assistance.
2. NARCAN® (naloxone hydrochloride) Nasal Spray is an opioid antagonist indicated for the emergency treatment of known or suspected opioid overdose, as manifested by respiratory and/or central nervous system depression.
3. With a simple to follow usage guide, pharmacy locater and training videos, you can ensure you are ready-to-use NARCAN Nasal Spray in the event of an opioid overdose emergency.
4. Precipitation of Severe Opioid Withdrawal: Use in patients who are opioid dependent may precipitate opioid withdrawal characterized by body aches, diarrhea, increased heart rate (tachycardia), fever, runny nose, sneezing, goose bumps (piloerection), sweating, yawning, nausea or vomiting, nervousness, restlessness or irritability, shivering or trembling, abdominal cramps, weakness, and increased blood pressure.
5. The following adverse reactions were observed in a NARCAN Nasal Spray clinical study: increased blood pressure, musculoskeletal pain, headache, nasal dryness, nasal edema, nasal congestion, and nasal inflammation.
6. NARCAN® Nasal Spray is contraindicated in patients known to be hypersensitive to naloxone hydrochloride.
7. NARCAN® Nasal Spray is intended for immediate administration as emergency therapy in settings where opioids may be present.
8. NARCAN® Nasal Spray is not a substitute for emergency medical care.
9. NARCAN Now is your tool for up-to-date product and safety information for NARCAN® Nasal Spray.
10. NARCAN Now is the official app for NARCAN® (naloxone HCL) Nasal Spray.
11. Risk of Cardiovascular (CV) Effects: Abrupt postoperative reversal of opioid depression may result in adverse CV effects.
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